Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1993-12-02
1995-07-04
Cintins, Marianne M.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
514221, 514415, 514923, A61K 3155, A61K 31405
Patent
active
054300290
ABSTRACT:
The present invention relates to new pharmaceutical compositions active in the therapy of sleep disorders comprising N-acetyl-5-methoxy-triptamine (melatonin) or one of its derivatives, preferably 2-iodo-N-acetyl-5-methoxy-triptamine (2-iodomelatonin), 2-bromo-N-acetyl-5-methoxy-triptamine (2-bromomelatonin), 2-chloro-N-acetyl-5-methoxy-triptamine (2-chloromelatonin) or 6-chloro-N-acetyl-5-methoxy-triptamine (6-chloromelatonin), at a dosage comprised between 10 and 100 mg, preferably comprised respectively between 20 and 80 mg between 10 and 20 mg and between 10 and 40 mg alone or in association with a benzodiazepinic derivative at a dosage comprised between 0.06 and 25 mg.
REFERENCES:
Chemical Abstracts 85: 53744z, 1976.
Chemical Abstracts 97: 86519p, 1982.
Chemical Abstracts 100: 185660q, 1984.
Sleep, vol. 13, No. 3, Jun. 1990, pp. 232-244, Raven Press, Ltd, N.Y., US; . Copinschi et al.
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Endocrinologia Japonica, vol. 33, No. 3, Jun. 1986, pp. 405-4.+-.4; M. Kabuto et al.
Biochemical Pharmacology, vol. 40, No. 12, 15th Dec. 1990, pp. 2701-2705, Pergamon Press, Oxford, GB, Niles et al.
Biella Gabriele
Fraschini Franco
Stankov Bojidar
Strambi Luigi F.
Cintins Marianne M.
Iflo-Istituto Farmacologico Lombardo S.A.S. di Giorgio e Ald. La
Jordan Kimberly R.
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