Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1976-12-15
1983-07-12
Reamer, James H.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
564328, 564430, 424311, 424330, 424337, 424340, 424341, 424346, 424347, 424348, 424343, 568 29, 568 30, 568 31, 568306, 568332, 568333, 568637, 568636, 568639, 568638, 568 42, 568 43, 568329, 568330, 568807, 568808, 568 28, 568 32, 568 33, 568 44, A61K 3112, C07C 49248
Patent
active
043930794
ABSTRACT:
Anti-inflammatory compositions are prepared which comprise a therapeutically effective amount of a compound of the formula ##STR1## wherein X is CO or CHOH; Y is CO; the dotted line represents a double bond which is present or absent; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen, fluorine, chlorine, bromine, methyl, trifluoromethyl, methoxyl, hydroxyl, acetoxyl, nitro or amino; R.sub.3 is alkyl of 3 to 8 carbon atoms, cycloalkyl of 3 to 8 carbon atoms, alkenyl of 3 to 8 carbon atoms, cycloalkenyl of 5 to 8 carbon atoms or phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino. Compounds of formula I above are also novel.
REFERENCES:
patent: 3924002 (1975-12-01), Duennenberger et al.
patent: 3931302 (1976-01-01), Allais et al.
patent: 3950427 (1976-04-01), Engel et al.
Cole William G.
Goudie Alexander C.
Rose Carl J.
Beecham Group Limited
Reamer James H.
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