Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1978-02-17
1980-08-05
Helfin, Bernard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424330, 424311, 260574, 260575, 560250, 568325, C07C 4944, A01N 924
Patent
active
042162327
ABSTRACT:
Anti-inflammatory compositions are prepared which comprise a therapeutically effective effective amount of a compound of the formula ##STR1## wherein X is CO; Y is an oxygen atom; the dotted line represents a double bond which is present or absent; R.sub.1 is hydrogen or methyl; R.sub.2 is hydrogen; and R.sub.3 is phenyl unsubstituted or substituted by 1 or 2 substituents selected from the group consisting of fluorine, chlorine, bromine, methyl, ethyl, methoxyl, ethoxyl, benzyloxyl, hydroxyl, acetoxyl, trifluoromethyl, nitro, amino, acetyl, methylthiol, methylsulphonyl, methylamino and dimethylamino; in combination with a pharmaceutically acceptable carrier. Methods of treating inflammation utilizing the compounds of formula (I) are part of the present invention together with the compounds themselves of the above formula.
REFERENCES:
patent: 3950427 (1976-04-01), Engel et al.
patent: 3962459 (1976-06-01), Kathala
patent: 3987102 (1976-10-01), Karrer
Cole William G.
Goudie Alexander C.
Rose Carl J.
Beecham Group Limited
Helfin Bernard
Reamer James H.
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