Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-05-01
1998-12-08
Kight, John
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514 42, 424450, 424461, A61K 31715, A61K 962, A61K 9127
Patent
active
058469516
ABSTRACT:
Polysaccharides comprising at least 5 sialic acid residues per molecule are used to increase the circulation time of an active ingredient, for instance by decreasing the immunogenicity and/or increasing the stability in vivo of pharmaceutically active compounds. The pharmaceutically active compound may be a foreign protein which is covalently bound to the polysaccharide. Alternatively, the active compound may be associated with a drug delivery system (DDS), for instance a macro-molecular DDS or a particulate DDS, such as liposomes. The polysaccharide is usually a bacterial polysaccharide, e.g., a glycolipid or a derivative thereof, for instance polysaccharide B or E. Coli K1, N. meningitidis, Moraxella liquifaciens or Pasteurella aeroginosis, or K92 of E. Coli K92 strain.
REFERENCES:
patent: 4501728 (1985-02-01), Geho et al.
patent: 4837028 (1989-06-01), Allen
patent: 5000959 (1991-03-01), Iga
Biochemica et Biophysica Acta, vol. 986, 1989, Amsterdam, NL, pp. 106-114, Abstract Pinnaduwge et al `The Role of Protein-Linked Oligosaccharide in the Bilayer Staliziation Activity of Glycophorin A For Dioleoylphosphatidylethanolamine Liposomes`.
Biochemica et Biophysica Acta, vol. 1023, 1990, Amsterdam, NL, pp. 357-364, Abstract Decher et al `Giant Liposomes as Model Membranes for Immunological Studies: Spontaneous Insertion of Purified K1-Antigen (Poly-Alpha-2,8-Neuac) of Escherichia Coli`.
Chemical Abstracts, vol. 107, 1987, Columbus, Ohio, US; Abstract No. 28327p, Sunamoto et al `Utilization of Functionalized Liposomes as Improved Artificial Cells` p. 319; col. 2; see abstract & Kenkyu Hokoku-Asahi Garasu Kogyo Gijutsu Shoreikai, vol. 48, 1986, pp. 231-239, Sunamoto et al.
Journal of Immunology, vol. 127, No. 3, Sep. 1981, Baltimore, USA, pp. 1011-1018, Jennings et al `Immunochemistry of Groups A, B and C Meningococcal Polysaccharide-Tetanus Toxoid Conjugates` cited in the application -- see the whole document.
Yamauchi et al., Int. J. Pharm., vol. 113(3): 141-148, (1995). Abstract only.
Sunamoto et al., Chem. Lett., vol. 10 : 1781-1784, (1988). Abstract only.
Carbohydr. Res. vol 156 (1986) Lifely et al. (abstract only).
Kight John
Lee Howard C.
The School of Pharmacy, University of London
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