Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1978-05-18

1982-06-29

Robinson, Douglas W.

Drug, bio-affecting and body treating compositions

Antigen, epitope, or other immunospecific immunoeffector

Bacterium or component thereof or substance produced by said...

424253, 424258, 424263, 424285, A61K 31505, A61K 3152, A61K 3144, A61K 3134

Patent

active

043372546

ABSTRACT:
Pharmaceutical combinations comprising (a) prostacyclin, dihydroprostacyclin or a pharmaceutically acceptable salt of either of these, and (b) a phosphodiesterase inhibitor. Pharmaceutical formulations comprising a combination as above and a pharmaceutically acceptable carrier. Methods are disclosed for preparing the combinations and the formulations.
The combinations and formulations are useful for preventing or minimizing platelet aggregation in blood, blood products or blood substitutes for example in the treatment of thrombosis, gastric lesions and wounds, and in the extra-corporeal circulation of blood and in blood separation processes.

REFERENCES:
patent: 3954787 (1976-05-01), Monkhouse
patent: 3962243 (1976-06-01), Roldan et al.
patent: 3998953 (1976-12-01), Konz et al.
patent: 4009282 (1977-02-01), Voorhees
patent: 4051236 (1977-09-01), Harris et al.
patent: 4158667 (1979-06-01), Axen
Prostaglandins 13 (3), 377-388 (1977)--Gorman et al.
Prostaglandins 14 (1), 39-50 (1977)--Gerrard et al.
Brit. J. Pharm. 59 (3) 438-439P (1977)--Bonta et al.
Prostaglandins 13 (3) 389-397 (1977)--Tateson et al.
Pharmacol. of Platelet Aggre. Inhibit.--Thomb. Diath. Haemorrh Suppl. 42, pp. 175-184 (1970)--Mills et al.
Biochem. Biophy. Res. Commn. 76 (3) 828-835 (1977)--Lapetina et al.
Biochem. J. 120, pp. 709-718 (1970)--Ball et al.
Nature 267, pp. 850-852 (1977) Best et al.
Biochem. J. 121, 185-196 (1971) Mills et al.

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