Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1995-06-07
1996-11-26
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
A61K 3142
Patent
active
055786260
ABSTRACT:
Compounds of formula (I) ##STR1## in which R.sub.1 represents hydrogen, a C.sub.1-6 aliphatic hydrocarbyl group or a C.sub.1-4 aliphatic hydrocarbyl group substituted by a C.sub.3-6 alicyclic hydrocarbyl group or by a phenyl group, which phenyl group is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.2 represents hydrogen, R.sub.3 represents hydrogen, a 5-or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur which is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, or a group AR wherein A is a straight chain C.sub.1-4 aliphatic hydrocarbyl group terminally substituted by R which is hydrogen, a phenyl group or a 5-or 6-membered ring aromatic heterocyclyl group containing one or two heteroatoms selected from nitrogen, oxygen and sulphur, which phenyl or heterocyclyl group R is unsubstituted or substituted by a halogeno or C.sub.1-3 halogenoalkyl group, R.sub.4 and R.sub.5 each represent hydrogen or together represent an oxo group and R.sub.6, R.sub.7 and R.sub.8 each represent hydrogen, or R.sub.4 represents hydrogen and two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 together represent the second bond of a double bond joining positions 4 and 5, 5 and 6 or 6 and 7 with the remaining two of R.sub.5, R.sub.6, R.sub.7 and R.sub.8 representing hydrogen, the compound optionally being in the form of a salt thereof formed with a physiologically acceptable inorganic or organic acid, are of value for the treatment of anxiety and in the improvement of learning ability and/or the reversal of amnesia.
REFERENCES:
patent: 4452799 (1984-06-01), Temple et al.
patent: 5049564 (1991-09-01), DeBernardis et al.
patent: 5114936 (1992-05-01), Wettlaufer et al.
I. Furukawa et al. "Direct synthesis of isoxazoline derivatives . . . " Chemical Abstracts #159012v, 1991, 115, p. 926.
F. A. Lakhvich et al. "Reductive cleavage of 4,5-cycloalkanoisoxazolines", Chemical Abstracts#135125e, 1989, 110, p. 705.
D. P. Curran et al. ". . . Regio and Stereoselective Exo Alkylation. . . " Journal of the American Chemical Society, 1987, 109, pp. 3036-3040.
D. P. Curran "Reduction of .increment..sup.2 -Isoxazolines . . . ", Journal of the American Chemical Society,1982, 104, pp. 4024-4026.
D. P. Curran et al. "Reduction of substituted .increment..sup.2 -Isoxazolines . . . ", Journal Organic Chemistry, 1984, 49, pp. 3474-3478.
P. A. Wade et al., "Benzenesulfonylnitrile oxide . . . ", Journal of the American Chemical Society, 1979, 101, pp. 1319-1320.
G. Zinner et al. ". . . synthesis of 4,5-tetramethylene-.increment..sup.2 -isoxazolines", Chemische Berichte, 1965, 98, pp. 1353-1354.
S. Mzengeza et al. "Dipolar cycloaddition reactions . . . "Journal of the Chemical Society, Chemical Communications 194. Letchworth, GB, pp. 606-607. 1984.
A. Vasella. "Stereoselektivitat und . . . " Helvetica Chimica Acta, vol. 60 No. 4, 1 Jun. 1966, Basel CH, pp. 1273-1295.
J. T. Bailey et al. "Annelation of cyclic dienes to amino . . . "Journal of Organic Chemistry, vol. 47 No. 5, 26 Feb. 1982, Easton, US, pp. 857-863.
Boyd Edward A.
Costall Brenda
Kelly Mary E.
Parsons Philip J.
British Technology Group Limited
Robinson Allen J.
LandOfFree
Pharmaceutical compositions does not yet have a rating. At this time, there are no reviews or comments for this patent.
If you have personal experience with Pharmaceutical compositions, we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical compositions will most certainly appreciate the feedback.
Profile ID: LFUS-PAI-O-1973528