Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1988-12-30

1990-01-30

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Tablets, lozenges, or pills

424480, 514202, A61K 928, A61K 936, A61K 3171

Patent

active

048972703

ABSTRACT:
A pharmaceutical tablet is described which comprises a tablet core containing the antibiotic cefuroxime axetil and a film coat which serves to mask the bitter taste of the cefuroxime axetil upon oral administration. It has been found that conventional film-coated tablets reduce the bioavailability of cefuroxime axetil and the invention overcomes this by control of the film coat rupture time and use of a tablet core which disintegrates immediately following rupture of the film coat.

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