Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1977-03-24

1978-07-25

Milestone, Norma S.

Drug, bio-affecting and body treating compositions

Nonspecific immunoeffector, per se ; or nonspecific...

Synthetic or structurally-modified peptidoglycan or...

2603436, C07D49304

Patent

active

041030230

ABSTRACT:
Pharmaceutical compositions containing 3,3a,6,6a-tetrahydrofuro[3,4-b]furan derivatives including canadensolide and 3-epi-dihydrocanadensolide. Novel 3,3a,6,6a-tetrahydrofuro[3,4-b]furan derivatives bearing a variety of substituents in the 3- and 6-positions selected from alkyl, phenyl, alkoxycarbonyl, methylene, benzylthiomethyl and optionally substituted phenylthiomethyl. The compositions and novel compounds show anti-ulcer activity and are useful in the treatment of gastric or duodenal ulcers.

REFERENCES:
patent: 3930014 (1975-12-01), Aldridge et al.
A. R. Oyler, Jour. Org. Chem. 41 (1976), pp. 4065-4069.
Yoshikoshi, Chem. Abstracts, vol. 79 (1973), 66337d, 66338d.
Zalinyan et al., Chem. Abstracts, vol. 81, 3701n.
Mukaiyama et al., Chem. Abstracts, vol. 74, 76349u.
R. Fittig, Annalen (1899) vol. 304, 322; vol. 305; 16.
H. Stobbe, Annalen (1899) vol. 308, 151, 165, 166.
Jennen, Chem. Abstracts, vol. 32, 500 (1931).
R. M. Carlson et al., Jour. Org. Chem. (1976), vol. 41, 4065-4069.

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