Drug – bio-affecting and body treating compositions – Solid synthetic organic polymer as designated organic active... – Polymer from ethylenic monomers only
Patent
1981-12-31
1984-01-24
Rose, Shep K.
Drug, bio-affecting and body treating compositions
Solid synthetic organic polymer as designated organic active...
Polymer from ethylenic monomers only
424238, 424241, 424242, 424243, A61K 916, A61K 942, A61K 31575, A61K 4700
Patent
active
044276494
ABSTRACT:
Pharmaceutical liposome compositions containing an anti-inflammatory steroid derivative bearing a lipophilic substituent, for example cortisol 21-hexadecanoate. Method of treatment of inflammation at a site involving an enclosed cavity, for example the treatment of rheumatic disease, comprising injecting a said pharmaceutical liposome composition into said cavity. Specified new steroid derivatives, for example fluocinolone acetamide 21-hexadecanoate.
REFERENCES:
Hollander (1955) Ann. N.Y. Acad. Sci. 61: 511-516, the Use of Intra-Articular Hydrocortisone, its Analogs and its Higher Esters in Arthritis.
Hollander (1972)"Arthritis and Allied Conditions" Hollander, J. L. and McCarthy, D. J. Eds. 8th Ed. p. 517-534 Lea and Fibiger, Philadelphia, Pa.
Goetzel et al., (Goetzel) Ann. Rheum. Dis. 33: 62-66 (1974) Effects of Intra-Articular Corticosteroids in Vivo on Synovial Fluid Variables in Rheumatoid Synovitis.
Shaw et al., (Shaw) Biochem. J. (1976) 158: 473-476 "Lipo Somal Retention of a Modified Anti-Inflammatory Steroid".
Segal et al., (Segal) Clinical Science & Molecular Medicine 49: 99-106 (1975) Liposomes as Vehicles for the Local Release of Drugs.
Stevens et al., (Stevens) CA. 78, No. 79949H (1973) of F.E.B.S. Lett. (1972) 27(1) 145-148, "Effect of Side Chain Structure on the Incorporation of Steroids into Lipid Bilayers (Liposomes)".
Heap et al., (Heap), Ca.74, No. 72170F (1971) to Biochem. Biophys. Acta. (1970) 218 (3): 482-495, "Steroids and their Interactions with Phospholipids, Solubility, Distribution Coefficient and Effect on Potassium Permebility of Liposomes".
Smith et al., (Smith) Ca. 82, No. 13324ot (1975) of Biochem. Soc. Trans. (1974) 2(5): 962-963 Nuclear Magnetic Resonance Studies of Phospholipid-Steroid Relations in Lipid Bilayers.
Dingle John T.
Gordon John L.
Jones Geraint
Knight Clive G.
Lowe John S.
Imperial Chemical Industries Limited
National Research Development Corporation
Rose Shep K.
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