Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1989-03-02

1991-07-02

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Effervescent or pressurized fluid containing

Organic pressurized fluid

424 48, 424647, 514184, 514502, A61K 904, A61K 968, A61K 31555

Patent

active

050284118

ABSTRACT:
Pharmaceutical compositions for the buccal or nasal administration of a neutral 3:1 hydroxypyrone:iron(III) complex of 3-hydroxy-4-pyrone or of a 3-hydroxy-4-pyrone in which one or more of the hydrogen atoms attached to ring carbon atoms are replaced by an aliphatic hydrocarbon group of 1 to 6 carbon atoms are of value for the treatment of iron deficiency anaemia.

REFERENCES:
patent: 2865938 (1958-12-01), Rosenfelder
patent: 2904573 (1959-09-01), Oroshnik et al.
patent: 3130204 (1964-04-01), Tate et al.
patent: 3338718 (1967-08-01), Olson
patent: 3376317 (1968-04-01), Stephens et al.
patent: 3821192 (1974-06-01), Montgomery et al.
patent: 4018907 (1977-04-01), Scarpellino
patent: 4018934 (1977-04-01), Parliment
patent: 4058621 (1977-11-01), Hill
patent: 4311691 (1982-01-01), Fichera
patent: 4315942 (1982-02-01), Corden
patent: 4575502 (1986-03-01), Hilder et al.
European Search Report: re: (Corresponding European Patent Applications-EPA 94,194; EPA 107,458; and Chem. Abstracts, vol. 75, No. 18 (Nov. 1, 1971)).
United Kingdom Search Report: re: (Corresponding U.K. Patent Application-GB 2128998 [equivalent of U.S. Ser. No. 542,976, already cited]).
Weatherall et al (Eds.), Oxford Textbook Medicine, Oxford University Press, 1983, vol. 1, p. 7.7.
Martindale, The Extra Pharmacopoeia, The Pharmaceutical Press, 1973, pp. 81 and 739.
Tate et al., U.S. application Ser. No. 314,141 filed 09/19/63.
Kimura et al, Chem. Pharm. Bull. (1980), 28, 2570-2579, "Central Depressant Effects of Maltol Analogs in Mice".
Pitt and Gupta (1975), pp. 137-173, Proceedings of a Symposium, "Development of Iron Chelators for Clinical Use", Anderson & Miller (Eds.), Pfizer Technical Bulletin, 04/A/Mar. 1974.
Pfizer, Technical Bulletin No. 865 and No. 867, Data Sheet.
Johnson & Thomas, Pharmaceutical Society of Great Britain Scientific Publications Department, pp. 1037-1047, "The Stability of Aqueous Solutions of Ferrous Gluconate".
Gerard & Hugel, J. Chem. Research (S), 1980, p. 314, "Iron(III) Complexes of Maltol (3-Hydroxy-2-methyl-4-pyrone), including Hydroxo-complexes, in an Acidic Medium".
Habeeb et al., J. Coord. Chem., (1978), 8, 27-33, "Direct Electrochemical Synthesis of some Metal Chelate Complexes".
Grady et al., J. of Pharm. & Exp. Therapeutics, (1976), 196, 478-485, "The Development of New Iron-Chelating Drugs".
Ganeshaguru et al., Biochem. Pharmacol., (1980), 29, 1275-1279, "Effect of Various Iron Clelating Agents on DNA Synthesis in Human Cells".
White et al., Brit. J. Haem., (1976), 33, 487-495, "The Use of Chang Cells Cultured in Vitro to Evaluate Potential Iron Chelating Drugs".
Stefanovic et al., Collection Czech. Chem. Commun., (1968), 33, 4198-4214, "On the Reaction of Iron(III) with Maltol".
Lieberman & Lachman, Pharmaceutical Dosage Forms, (1982), 3, 165-167, Marcel Decker.
E. Jones, Manufacturing Chemist & Aerosol News, May 1970, "Production of Enteric Coated Capsules".
Blake, undated, "Study to Compare the Effect of Iron Maltol versus Ferrous Sulphate in the Correction of Chronic Iron Deficiency Anaemia".
Maxton et al., Jan. 1986, "Report of Iron Uptake from Fe(III) Maltol", Human Studies.
Skikne, Feb. 14, 1986, Letter.
Hider, Structure and Bonding, (1984), 58, 25-87, "Siderophore Mediated Absorption of Iron".
The Merck Index, (1976), 9th Edition, Merck & Co., Inc., Rahway, N.J., 543-544.
Kidani et al., Nagoya Shiritsu Daigaku Yakugakubu Kenkyu Nempo, (1970), 18, 16-21, "Synthesis of Maltol-Fe(III) Complex".
Chemical Abstracts, 75:115362k, (1971).
Chemical Abstracts, 94:24201h, (1981).
Chemical Abstracts, 94:41144j, (1981).
Chemical Abstracts, 94:156749c, (1981).
Chemical Abstracts, 98:71930n, (1983).
Foye & Lo, J. Pharm. Sci., (1972), 61, 1209-1212, "Metal-Binding Abilities of Antibacterial Heterocyclic Thiones".
Akers et al., J. Bacteriol., (1980), 141, 164-168, "Thujaplicins from Thuja plicata as Iron Transport Agents for Salmonella typhimurium".
Bothwell et al., Amer. J. Cli. Nutr., (1964), 14, 47-51, "Iron Overload in Bantu Subjects".
Gerard et al., J. Chem. Research (M), (1980), paper F/016/80, 3919-3927.

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