Pharmaceutical compositions

Details Pharmaceutical compositions Pharmaceutical compositions

1977-09-20

1980-04-15

Rose, Shep K.

Drug, bio-affecting and body treating compositions

Solid synthetic organic polymer as designated organic active...

Polymer from ethylenic monomers only

424182, A61K 948, A61K 31705

Patent

active

041983912

ABSTRACT:
A cardiotonic dosage unit form comprises a soft gelatin capsule containing a liquid cardiotonic composition comprising (a) a cardiac glycoside, preferably digitoxin or digoxin; (b) ethanol; (c) water; (d) propylene glycol and/or glycerine; and (e) a liquid polyethylene glycol; the cardiac glycoside preferably being present in an amount of from 50 to 300 micrograms.

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(1971) Hagers, "Pharmazgutischen Praxis," Springer/Verlag, Berlin, Ger., Kapseln, pp. 482-491.
(1971) Boehringer, "Lanitop" B-methyl-digoxin, Nov. 1971, Dec. 1971, Kapseln, 12 pp., Misc. Adv. and Mfg. Prod. Inform.
(1972) Martindale Extra Pharmacopeia, 26th Ed., Pharm. Press, London, pp. 622-630, Digitalis Cardiac Elycosides.
(1973) British Pharmaceutical Codex. Pharm. Press., London, pp. 162-163 "Digitoxin-Digoxin".
Hom et al., J. Pharm. Sci. 59(6): 827-830, Jun. 1970 "Oral Dosage Form Design and its Influence on Dissolution Rates for a Series of Drugs".
Huffman et al., J.A.M.A. 222(8): 957-960, Nov. 20, 1972, "Absorption of Orally Given Digoxin Preparations.
Lindenbaum Pharmacol. Rev. 25(2): 229-237, Jun. 1973 "Bioavailability of Digoxin Tablets".
R. P. Scherer Corp. Annual Report (1974) 2 pp., (1973) 2 pp., (1972) 2 pp.

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