Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Reexamination Certificate
2005-06-14
2005-06-14
Nazario-Gonzalez, Porfirio (Department: 1621)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
C514S034000, C514S217110, C514S217120, C514S676000, C514S680000, C514S685000
Reexamination Certificate
active
06906059
ABSTRACT:
The use of benzazepin-N-acetic acid derivatives which contain an oxo group in the a position to the nitrogen atom and are substituted in the 3 position by a 1-(carboxyalkyl)-cyclopentyl-carbonyl-amino radical, and of their salts and biolabile esters, for the prophylaxis and/or treatment of heart damage caused by cardiotoxic doses of medicaments or chemicals, in larger mammals and in particular humans. The invention is particularly applicable to the prophylaxis and/or treatment of heart damage, in particular to the myocardium, which may occur during cytostatic chemotherapy. The invention also includes the use of the afore-mentioned benzazepin-N-acetic acid derivatives for adjuvant treatment in therapies in which medicaments having oxidative-toxic side-effects are used, and the preparation of medicaments suitable for this prophylaxis and/or treatment or adjuvant treatment.
REFERENCES:
patent: 5677297 (1997-10-01), Waldeck et al.
patent: 5783573 (1998-07-01), Rozsa et al.
patent: 6482820 (2002-11-01), Wilkins et al.
patent: WO 01/03699 (2001-01-01), None
International Search Report, (Dec. 15, 2000).
Lonovics Zsuzsanna
Papp Julius Gy.
Thormaehlen Dirk
Waldeck Harald
Crowell & Moring LLP
Nazario-Gonzalez Porfirio
Solvay Pharmaceuticals
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