Pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-H

Details Pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-H Pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-H

1993-09-07

1994-05-03

Schain, Howard E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 13, A61K 3724, A61K 3736

Patent

active

053088360

ABSTRACT:
There is disclosed a pharmaceutical composition of stabilized [Leu.sup.13 ]-motilin-Hse. The composition comprises at least one of organic acids and salts thereof, as a first stabilizer, and pH thereof is adjusted in a range of 5.5-8.0. The composition may contain at least one of substances selected from saccharides, amino acids, proteins and salts thereof, as a second stabilizer. Conversion of [Leu.sup.13 ]-motilin-Hse into [Leu.sup.13 ]-motilin-Hse-lactone is suppressed by increasing pH value and deamidization in asparagine residue at 19-position is suppressed by the presence of the organic acid or salt thereof.

REFERENCES:
patent: 5011824 (1991-04-01), Masada et al.

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