Pharmaceutical composition of poly(orthoester) co- and homopolym

Details Pharmaceutical composition of poly(orthoester) co- and homopolym Pharmaceutical composition of poly(orthoester) co- and homopolym

1977-10-19

1979-05-22

Moyer, Donald B.

Drug, bio-affecting and body treating compositions

Identification or warning feature

Taste or smell or chemical irritation to the eye, nose, or...

424 20, 424 32, 424 78, A61K 922, A61K 932, A61K 958, A61K 31765

Patent

active

041559924

ABSTRACT:
Poly(orthoester) co- and homopolymers and poly(orthocarbonate) co- and homopolymers comprising (1) a repeating dioxycarbon unit in the polymeric backbone having a plurality of organic groups pendant therefrom, and (2) a bridging moiety having at least one carbonyloxy group contained therein are disclosed. The polymers are represented by the formula: ##STR1## WHEREIN R is a bridging moiety and is either R.sub.1 or R.sub.2 arranged in a random manner along the polymeric backbone to form a copolymer containing both R.sub.1 and R.sub.2 with R.sub.1 an aliphatic, an alicyclic or an aromatic group and R.sub.2 is a ##STR2## GROUP WITH R.sub.1 as defined and R.sub.3 an aliphatic, an alicyclic or aromatic group, or wherein R is a bridging moiety and is only R.sub.2 to form a homopolymer with R.sub.1, R.sub.2, and R.sub.3 as defined above, and a is 0 to 1, b is 2 to 6, and n and the sum of x and y are positive integers. The copolymers are useful for making articles of manufacture, including devices and coatings for delivering beneficial agents.

REFERENCES:
patent: 3914402 (1975-10-01), Shell
patent: 3983209 (1976-09-01), Schmitt
patent: 4001388 (1977-01-01), Shell
patent: 4070347 (1978-01-01), Schmitt
patent: 4093709 (1978-06-01), Choi et al.

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