Pharmaceutical composition of nanoparticles for protein drug...

Details Pharmaceutical composition of nanoparticles for protein drug... Pharmaceutical composition of nanoparticles for protein drug...

2011-04-04

2011-11-01

Monshipouri, Maryam (Department: 1656)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

Reexamination Certificate

active

08048453

ABSTRACT:
The invention discloses a pharmaceutical composition of bioactive nanoparticles composed of chitosan, poly-glutamic acid, and a bioactive agent for oral delivery. The chitosan-based nanoparticles are characterized with a positive surface charge and enhanced permeability for oral drug delivery.

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van der Lubben Im et al. “Chitosan and its derivatives in mucosal drug and vaccine delivery” Euro J Pharma Sci 2001;14:201-207.
Hosny Ea et al. “Oral delivery of insulin from enteric-coated capsules containing sodium salicylate” Int J Pharmaceutics 2002;237:71-76.
Thanou M et al. “Chitosan and its derivatives as intestinal absorption enhancers” Adv. Drug Deliv. Rev. 2001;50:S91-S101.
Smith J et al. “Effect of chitosan on epithelial cell tight junctions” Pharmaceutical Research 2004;21:43-49.

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