Pharmaceutical composition of dihydropyridine compound

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Phosphorus containing other than solely as part of an...

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A61R 3166

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active

049835939

ABSTRACT:
A pharmaceutical composition comprising: a 1:1 solvate of 5-(5,5-dimethyl-1,3,2-dioxaphosphorinane-2-yl)-1,4-dihydro-2,6-dimethyl-4- (3- itrophenyl)-3-pyridine carboxylic acid 2-(phenylmethyl)amino) ethyl ester P-oxide hydrochloride-thanol (NZ-105) and hydroxypropylmethylcellulose acetate succinate is disclosed. the composition can easily be prepared into tablets, capsules, granules, and powders, which exhibit an enhanced bioavailability, e.g. provides a high blood concentration of the active component NZ-105 and ensures a high total drug absorption.

REFERENCES:
Chemical and Pharmaceutical Bulletin, vol. 35, No. 9, Sep. 1987, pp. 3935-3939, Pharmaceutical Society of Japan, Tokyo, JP; N. Ohnishi et al.

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