Pharmaceutical composition of aspirin and a benzothiazepine for

Details Pharmaceutical composition of aspirin and a benzothiazepine for Pharmaceutical composition of aspirin and a benzothiazepine for

1993-03-23

1995-02-07

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ortho-hydroxybenzoic acid or derivative doai

514211, 514264, A61K 3160, A61K 3155, A61K 3152

Patent

active

053875818

ABSTRACT:
There is disclosed a pharmaceutical composition for inhibiting the platelet aggregation comprising acetylsalicyclic acid or a pharmaceutically acceptable salt thereof and a 1,5-benzothiazepine derivative of the formula: ##STR1## wherein R.sup.1 is a lower alkyl group or a lower alkoxy group, R.sup.2 is hydrogen atom or a lower alkanoyl group, R.sup.3 is a lower alkyl group, R.sup.4 is hydrogen atom or a lower alkyl group and R.sup.5 is a lower alkyl group or a halogen atom, or a pharmaceutically acceptable salt thereof.

REFERENCES:
patent: 4567175 (1986-01-01), Takeda et al.
patent: 4590188 (1986-05-01), Takeda et al.
patent: 4594342 (1986-06-01), Takeda et al.
patent: 4724266 (1988-08-01), Satzinger et al.
patent: 4806530 (1989-02-01), Langer
CA: 107(15) #134332w (1987).
CA: 108(13) #112510w Takeda (1988).
CA: 108(1) #6054y Morimoto (1988).
International Drug Directory 1990/1991, p. 1141.

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