Pharmaceutical composition having thrombolytic activity

Details Pharmaceutical composition having thrombolytic activity Pharmaceutical composition having thrombolytic activity

1989-07-21

1992-12-29

Stone, Jacqueline

Drug, bio-affecting and body treating compositions

Enzyme or coenzyme containing

Multienzyme complexes or mixtures of enzymes

424 9464, 424 9463, 514822, A61K 3762, A61K 37547, A61K 3754

Patent

active

051749947

ABSTRACT:
Plasminogen activators of the tissue-type and plasminogen activators of the urokinase-type appear to have a synergistic action in vivo when administered together as thrombolytic agents. Use in pharmaceutical compositions and in methods for the preparation and use thereof are set forth.

REFERENCES:
patent: 3555000 (1971-01-01), Wagner
patent: 4285932 (1981-08-01), Smith
Zamarron et al., Thromb Haemostas, 52(1), 19-23 (1984).
Collen et al., Cited in Chem. Abstracts vol. 105:164686r (1986).
Collen et al., J. Pharmacol. Exp. Therap. vol. 231, No. 1 (1984) pp. 146-152.
Lijnen et al., Cited in Chem. Abstracts vol. 101:204095y (1984).
Zamarron et al., Cited in Chem. Abstracts vol. 101:204094x (1984).
Matsuo et al., Cited in Chem. Abstracts vol. 97:66201a (1982).

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