Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution... – Containing or obtained from panax or acanthopanax
Reexamination Certificate
2005-02-15
2005-02-15
Lilling, Herbert J. (Department: 1651)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Containing or obtained from panax or acanthopanax
C424S725000, C424S741000, C424S773000, C424S777000
Reexamination Certificate
active
06855346
ABSTRACT:
The present invention provides a method for treating patients with liver diseases by co-administrating a pharmaceutical composition and lamivudine to the patients. The pharmaceutical composition is a herbal mixture which contains, as the core ingredients, the aqueous extracts of the entire plant ofHerba Hedyotidis diffusae, the rhizome ofRhizoma Bistortae, the rhizome ofRhizoma Polygoni Cuspidati, and the ripe fruit ofFructus Schisandrae. The present invention also provides methods for preventing a relapse of hepatitis in patients after the lamivudine treatment has been discontinued and for suppressing the development of lamivudine drug resistance in patients by providing the lamivudine-treated patients with the pharmaceutical composition of the present invention.
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Balzarini, J. et al., Anti-HIV and Anti-HBV Activity and Resistance Profile of 2′, 3′-Dideoxy-3′-Thiacytidine (3TC) and its Arylphosphoramidate Derivative CF 1109; Biochemical and Biophysical Research Communications, vol. 225, p. 363-369, 1996.
Lai, C., et al., A One-Year Tiral of Lamivudine for Chronic Hepatitis B; The New England Journal of Medicine, vol. 339, No. 2, p. 61-68, 1998.
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Liaw, Y. et al., Acute Exacerbation and Hepatitis B Virus Clearance After Emergence of YMDD Motif Mutation During Lamivudine Therapy; Hepatology, vol. 30, No. 2, p. 567-572, 1999.
Bingham & McCutchen LLP
Chao Fei-Fei
Lilling Herbert J.
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