Pharmaceutical composition having an excellent absorption proper

Details Pharmaceutical composition having an excellent absorption proper Pharmaceutical composition having an excellent absorption proper

1985-01-14

1987-03-17

Waddell, Frederick E.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514 12, A61K 3726

Patent

active

046507850

ABSTRACT:
A compound represented by the formula: ##STR1## wherein R.sup.1 is a hydrogen atom, a fluorine atom, a nitro group, a hydroxyl group or a hydroxyl group protected by an esterifying group; X is CO or SO.sub.2 ; --Y-- is a straight bond, a lower alkylene group, a substituted or unsubstituted vinylene group, or group having the formula --CH.sub.2 --O-- or --O--CH.sub.2 --; R.sup.2 is a substituted or unsubstituted phenyl or naphthyl group, or R.sup.2 --Y--CO is N-benzyloxycarbonylphenylalanyl, N-benzyloxycarbonyl-4-fluorophenylalanyl or N-(m-methoxycinnamoyl)-phenylalanyl group; or a non-toxic salt thereof is disclosed along with pharmaceutical compositions containing these compounds and methods of using these compositions to increase the rate of absorption of medicines.

REFERENCES:
patent: 4261919 (1981-04-01), Knowles et al.
patent: 4380646 (1983-04-01), Franzmann
Israel Journal of Chemistry, vol. 12, No. 3, pp. 757-763 (1974) (Lustig et al).

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