Pharmaceutical composition having an excellent absorption proper

Details Pharmaceutical composition having an excellent absorption proper Pharmaceutical composition having an excellent absorption proper

1986-06-10

1987-06-02

Reamer, James H.

Organic compounds -- part of the class 532-570 series

Organic compounds

Carboxylic acids and salts thereof

562443, 562445, 562450, C07C10108

Patent

active

046705848

ABSTRACT:
An absorption promoter is disclosed which interacts with hydrophobic amino acid residues of polypeptide derivative medications and substantially increases the absorption of that medication administered orally or rectally. The promoter and medication can be compounded into unit dosages in capsule, tablet, or suppository form, or combined into elixir solutions, suspensions, etc. The absorption promoters are phenylalanine derivatives which may be prepared through conventional N-acylation techniques.

REFERENCES:
patent: 4380646 (1983-04-01), Franzmann
Vidugiriene et al, Chem. Abst., vol. 77, #152539k (1972).
Takeuchi et al, Chem. Abst., vol. 95, #144605k (1981).
Takeuchi et al, Chem. Abst., vol 99, #192,209p (1983).
Van Sumere et al, J. of Chromatography, vol. 234, pp. 141-155, (1982).

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