Pharmaceutical composition for treating papillomavirus...

Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant virus encoding one or more heterologous proteins...

Reexamination Certificate

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C424S204100, C435S320100, C435S069100, C435S006120

Reexamination Certificate

active

07118754

ABSTRACT:
A pharmaceutical composition for treating or preventing a papillomavirus infection or tumour, including, as the therapeutical agents, a polypeptide from an early region and a polypeptide from a late region of a papillomavirus, optionally combined with a polypeptide having immunostimulatory activity or a polypeptide from an early or late region of a papillomavirus and a polypeptide having immunostimulatory activity, or alternatively, a recombinant vector containing inserted DNA fragments coding for the above-mentioned polypeptide combinations.

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Gajewski, 1996, “B7.1 but not B7.2 Efficiently Costimulates CD8+ T Lymphocytes in the P815 Tumor Systemin vitro”,The Journal of Immunology,156:465-472.
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Munger et al., 1989, “Complex Formation of Human Papillomavirus E7 Proteins with the Retinoblastoma Tumor Suppressor Gene Product”,The EMBO Journal,8:4099-4105.
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