Pharmaceutical composition for treating osteoporosis

Details Pharmaceutical composition for treating osteoporosis Pharmaceutical composition for treating osteoporosis

1996-09-27

1997-10-21

Krass, Frederick

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Ketone doai

514687, A01N 3500, A61K 3111

Patent

active

056797168

ABSTRACT:
A therapeutic agent for osteoporosis comprising as an active ingredient xanthohumol. Xanthohumol obtained from hop extracts has a bone resorption inhibiting activity and is useful as a therapeutic agent for osteoporosis.

REFERENCES:
patent: 3794744 (1974-02-01), Gardner
patent: 4065574 (1977-12-01), Moon et al.
Chemical Abstracts 106:135069, "A New Flavanone w Antifungal Activity Isolated From Hops", Mizobuchi et al. 1985.
Mizobuchi et al., "A New Flavanone with Antifungal Activity Isolated From Hops," Rep. Res. Lab. Kirin Brew. Co., 28:33-38 (1985).
Chury, J., "Uber Den Phytoostrogengehalt Einiger Pflanzen," Experientia 16:194-95 (1960) (with English Translation).
Koch et al., "Ostrogene Hormone in Hopfen Und Bier," Munch. Med. Wschr. 95:845 (1953) (with English Translation).
Iwasa et al., "The Role of Female Sex Hormone in Osteoporosis--Effect of Whole Bone Metabolism," Journal of Clinical and Experimental Medicine 165(9):533-37 (1993) (with English Translation).
Fenselau et al., "Is Oestrogenic Activity Present in Hops?", Food Cosmet. Toxicol. 11:597-603 (1973).
Hoffman, B., "A Modified Detection Reaction for Oestrogens on Paper Chromatograms and Thin Layer Chromatograms," J. Chromatog. 34:269 (1968) (with English Translation).
Mizobuchi et al., "Antifungal Activities of Hop Bitter Resins and Related Compounds," Agric. Biol. Chem. 49(2):399-403 (1985).
Verzele et al., "Xanthohumol, A New Natural Chalkone," Bull. Soc. Chim. Belg. 66:452-75 (1957).
Hansel et al., "Demethylxanthohumol: Isolation from Hops and Cyclization to Flavanones," Arch. Pharm. (Weinheim) 321:37-40 (1988) (with English Translation).
Chemical Abstracts, 102:75700, "A New Flavanone with Antifungal Activity Isolated From Hops" Agric. Biol. Chem. (1984), 48(11), 2771-5.
Holzl et al., "Inhaltsstoffe Des Hopfens," Zeitschrift fur Phytotherapie 13(5):155-61 (1992) (with English Translation).

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