Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Implant or insert
Patent
1998-09-01
2000-10-03
Azpuru, Carlos A.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Implant or insert
424430, 5147726, A61F 1302, A61F 606
Patent
active
06126959&
ABSTRACT:
The present invention teaches a composition comprising a .beta.-adrenergic agonist in a bioadhesive carrier. Preferably, the composition comprises terbutaline in polycarbophil. The present invention additionally teaches the local administration of a .beta.-adrenergic agonist for the purpose of treating or preventing dysmenorrhea or premature labor. Using this composition and the method of treatment provides sufficient local levels of the drug to provide therapeutic efficacy, but avoids many untoward adverse events.
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Lalos, O. et al., "Effect of salbutamol on the non-pregnant human uterus in vivo," Acta Obstet Gynecol Scand, vol. 60, No. 4 (1981), 349-352.
Lockwood, C.J., "The diagnosis of preterm labor and the prediction of preterm delivery," Clinical Obstetrics ad Gynecology, vol. 38, No. 4 (Dec. 1995) 675-687.
Lyrenas, S. et al., "Pharmacokinetics of terbutaline during pregnancy," Eur J Clin Pharmacol, vol. 29, No. 5 (1986) 619-623.
McCombs, J., "Update on tocolytic therapy," The Annals of Pharmacotherapy, vol. 29, No. 5 (May 1995) 515-522.
Miles, R.A. et al., "Pharmacokinetics and endometerial tissue levels of progesterone after administration by intramuscular and vaginal routes: a comparative study," Fertility and Sterility, vol. 62, No. 3 (Sep. 1994) 485-490.
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Nyberg, L., "Pharmacokinetic parameters of terbutaline in healthy man. An overview," Eur J Resp Dis vol. 65 Suppl. 134 (1984) 149-160.
Park, H. et al., "Physico-chemical properties of water insoluble polymers important to mucin/epithelial adhesion," Journal of Controlled Release, vol. 2 (1985) 47-57.
Ripe, E. et al., "Oral administration of terbutaline in asthmatic patients," Eur J Resp Dis, vol. 65, Suppl. 134 (1984) 171-179.
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Bologna William J.
de Ziegler Dominique
Levine Howard L.
Azpuru Carlos A.
Columbia Laboratories, Inc.
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