Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Patent
1987-02-04
1989-08-08
Robinson, Allen J.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
514356, 514929, A61K 3144, A61K 3152
Patent
active
048553000
ABSTRACT:
A pharmaceutical combination preparation and method for the treatment of circulatory disturbances comprising a dihydropyridine of the formula ##STR1## in which --R.sub.1, is a CH.sub.3 --O--CH.sub.2 --CH.sub.2 -- or CH.sub.3 group; R.sub.2 is a ##STR2## or CH.sub.3 --CH.sub.2 -- group; R.sub.3 is 4, NO.sub.2 or CL; and R.sub.2 is NO.sub.2, H or CL; and pharmaceutically suitable salts thereof; as active substance A and Pentoxifylline as active substance B, the quantity ratios of A:B being from about 1:150 to about 1:2.
REFERENCES:
patent: 3422107 (1969-01-01), Mohler et al.
patent: 4504476 (1985-03-01), Schwartz et al.
The Merck Index 10th Ed. (1983) pp. 931, 936, 937, 569, 1025 and 1026.
K. U. Benner, "Klinische Hamorheologie: Grundlagen und Geschichte", GIT Labor-Medizin, 5/85 pp. 295, 296, 300, 301 & 302.
A. Fleckenstein, R. Roskamm, "Consequences of Uncontrolled Calcium Entry and its Prevention with Calcium Antagonists", English Publication of Fleckenstein from European Heart Journal, 4, Supplement H,43-50, 1983, corresponding to the cited article.
R. Muller, Therapiewoche 30, 1980, the relevant passages have been translated into English.
Dettelbach et al., Journal of Clinical Pharmacology, 1985.
Aviado et al., Pharmacotherapy, vol. 4, No. 6, 1984, "Pentoxifylline: A New Drug for the Treatment of Intermittent Claudication".
Fischer Helga
Herrmann Wilfried
Kohne Hans
Lahr Wolfgang
Nandi Kumaresh
Dr. Rentschler Arzneimittel GmbH & Co.
Robinson Allen J.
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