Pharmaceutical composition for the treatment of blood coagulatio

Details Pharmaceutical composition for the treatment of blood coagulatio Pharmaceutical composition for the treatment of blood coagulatio

1996-08-22

1999-04-06

Tsang, Cecilia J.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Peptide containing doai

514834, 530381, 530384, 424101, A01N 3718, A61K 3800, A61K 3514, C07K 100

Patent

active

058918434

ABSTRACT:
The invention relates to a pharmaceutical composition for the treatment of patients with blood coagulation diseases which are caused by coagulation factor deficiency and/or inhibitors of coagulation factors, whereby the composition has a FEIB-activity and is characterized in that it has Factor VIIa and at least one further active ingredient and the activity of at least 10 Factor VIIa units per unit FEIBA. Additionally, the invention comprises a method for the production of the pharmaceutical preparation and its use.

REFERENCES:
patent: 4287180 (1981-09-01), Thomas
Mariani, Russo, Mandelli, Acovated Prothrombin Complex Concentrates, Praeger, Chpt. 11 pp. 77-87, 1982.
Sander et al., Folia Haematol 117(4): 581-587 (1990), ISSN 0323-4347 Abstract only considered.
Wilms et al., Folia Haematol 117(4): 589-593 (1990), ISSN 0323-4347 Abstract only considered.
H. Vinazzer, Thrombosis Research 26:21-29 (1982).
Meili et al., Schweiz Med Wochenschr 125: 405-411 (1995) Abstract only considered.
Research Disclosure 269: 94-95 (Sep. 1986), Great Britian.
Rote Liste 1993.
Mariani et al., "Contact Activation and Factor VII After the Use of an Activated Prothrombin Complex Concentrate (FEIBA) in Hemophiliacs w/Inhibitors", Thromb. Res. vol. 31, (1983), pp. 475-488.
Teitel, "The Factor VIII Bypassing Activity of Prothrombin Complex Concentrates: the Roles of Factor of Vlla and of Endothelial Cell Tissue Factor", Throm. & Hemo., vol. 66, No. 5, (1991), pp. 559-564.
Headner et al., "Clinical Experience with Human Plasma-Derived Factor Vlla in Patients with Hemophilia A and High Titer Inhibitors", Hemostasis, vol. 19, (1989), pp. 335-343.
Vinazzer, "Comparison Between Two Concentrates with Factor VIII Inhibitor Bypassing Activity", Thrombosis Research, vol. 26, (1982), pp. 21-29.
Deijk, "Evaluation of a Coagulation Assay Determing the Activity State of Factor VII in Plasma", Hemostasis, vol. 13, (1983), pp. 192-197.
Morrissey et al., "Quantitation of Activated Factor VII Levels in Plasma Using a Tissue Factor Mutant Selec. Deficient in Promoting Factor VII Activation", Amer. Soc. Hemato., vol. 81, No. 3, (1993) pp. 734-744.
Bradford, "A Rapid and Sensitive Method for the Quantitation of Microgram Quantites of Protein Utilizing the Principle of Protein-Dye Binding", Anal Biochem., vol. 72, (1976), pp. 248-254.
Giles et al., "A Canine Model of Hemophilic (Factor VIII:C Deficiency) Bleeding", Blood, vol. 60, No. 3, (1982), pp. 727-730.
Curling, "Albumin Purification by Ion Exchange Chromatography", Methods of Plasma Protein Fractionation, Academic Press, (1980), pp. 77-97.

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