Pharmaceutical composition for protecting the heart comprising a

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

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A61K 3144

Patent

active

050828517

ABSTRACT:
The invention provides a composition for protecting the heart from myocardial ischemia and reperfusion injury as well as for reducing post-ischemic damage, improving cardiac function and serving as a hypothermic cardiac preservative solution comprising N,N,N'N'-tetrakis-(2-pyridylmethyl)-ethylenediamine (TPEN) as active ingredient therein.

REFERENCES:
Shlafer et al., J. Thorac. Cardiovasc. Surg., 83, 830-839 (1929).
Stewart et al., J.Thorac. Cardiovasc. Surg., 86, 262-272 (1983).
Myers et al., J. Mol. Cell Cardiol., 17, 675-684 (1985).
Meerson et al., Basic Res. Cardiol., 77, 465-485 (1982).
Chem. Abst., III: 111515b (1989). Nagano et al.
Chem. Abst. 103:16658b (1985). Burton.
Chem. Abst. 110:5474 (1989). Aoki et al.

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