Drug – bio-affecting and body treating compositions – Plant material or plant extract of undetermined constitution...
Reexamination Certificate
2007-06-13
2010-06-08
Leith, Patricia (Department: 1655)
Drug, bio-affecting and body treating compositions
Plant material or plant extract of undetermined constitution...
Reexamination Certificate
active
07731994
ABSTRACT:
The present invention relates to a pharmaceutical composition for protecting neurons or for preventing and treating ischemic neuronal diseases comprising the extract ofLithospermum erythrorhizonSieb. Et Zucc extracted with water, low-alcohols or their mixture or acetylshikonin separated therefrom as an effective ingredient. The extract ofLithospermum erythrorhizonSieb. Et. Zucc or acetylshikonin separated therefrom of the present invention has neuronal protective effect, so that it not only interrupts the development of ischemic neuronal diseases but also is very safe, indicating that the extract or acetylshikonin can be used as a medicinal drug for prevention and treatment of degenerative brain disease caused by neuronal apoptosis such as stroke, apoplexy, dementia, Alzheimer's disease, Parkinson's disease, Huntington's disease, Pick's disease and Creutzfeldt-Jakob disease and further can be developed as functional health food.
REFERENCES:
patent: 5589154 (1996-12-01), Anderson
patent: 2006064068 (2006-06-01), None
patent: 10-2004-0102090 (2006-10-01), None
Vickers, J. C.; A Vaccine Aginst Alzheimer's Disease; Drugs Aging (2002), 19 (7) pp. 487-494.
Kermer et al. Neuronal Apoptosis in Neurodegenerative Diseases; From Basic Research to Clinical Application; Neurodegenerative Diseases, 2004,(1) pp. 9-19.
Bu Youngmin
Ha Ni Na
Kim Geum Soog
Kim Ho Cheol
Kim Yun Tai
Industry Academic Cooperation Foundation of Kyunghee University
Leith Patricia
Lucas & Mercanti LLP
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