Pharmaceutical composition for percutaneous drug absorption and

Details Pharmaceutical composition for percutaneous drug absorption and Pharmaceutical composition for percutaneous drug absorption and

1988-06-17

1991-09-03

Schenkman, Leonard

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

424449, 514947, A61K 3144

Patent

active

050455532

ABSTRACT:
The present invention relates to a pharmaceutical composition for percutaneous drug absorption which comprises 5-isopropyl 3-methyl 2-cyano-6-methyl-4-(3-nitrophenyl)-1,4-dihydropyridine-3,5-dicarboxylate, and ethanol and/or an unsaturated higher fatty acid and to a composition of matter which comprises ethanol and/or an unsaturated higher fatty acid and is capable of promoting percutaneous absorption of said dihydropyridine compound.

REFERENCES:
patent: 4338322 (1982-07-01), Sato
patent: 4379454 (1983-04-01), Campbell et al.
patent: 4460372 (1984-07-01), Campbell et al.
Chemical Abstracts 105: 158835x, 1986, (Kinoshita et al.).
E. R. Cooper, "Increased Skin Permeability for Lipophilic Molecules," J. Pharm. Sci., vol. 73, No. 8, pp. 1153-1156 (1984).
E. R. Cooper et al., "Effect of Fatty Acids and Alcohols on the Penetration of Acyclovir Across Human Skin in Vitro", J. Pharm. Sci., vol. 74, No. 6, pp. 688-689 (1985).

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