Pharmaceutical composition for intrarectal administration of a c

Details Pharmaceutical composition for intrarectal administration of a c Pharmaceutical composition for intrarectal administration of a c

1988-09-26

1990-09-04

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Implant or insert

424434, 424451, 424456, A61K 902, A61K 948

Patent

active

049543423

ABSTRACT:
New compositions containing a calcitonin as the active ingredient are described which are suitable for the intrarectal administration as soft gelatin capsules or microenemas, wherein the active principle, optionally admixed with a stabilizer, is dissolved in a liquid vehicle consisting of: (a) at least 70% by weight of a polyethylene or a polypropylene glycol or a mixture of polyethylene or polypropylene glycols with different molecular weights, having the consistency of a homogeneous fluid at room temperature, and (b) less than 15% by weight of a buffer in a pH range of from 4.5 to 6.5, and optionally (c) less than 15% by weight of an alcohol of 2 to 6 carbon atoms containing two or more hydroxy groups.
The new compositions, which do not contain any absorption aid, give calcitonin plasma levels comparable to a conventional intramuscular administration.

REFERENCES:
patent: 4151276 (1979-04-01), Caulin et al.
patent: 4613500 (1986-09-01), Suzuki et al.
patent: 4618598 (1986-10-01), Conn
patent: 4639338 (1987-01-01), Stahl et al.
patent: 4711880 (1987-12-01), Stahl et al.
"Enhanced Rectal Absorption of [Asu.sup.1,7 ]-eel Calcitonin in Rats Using Polyacrylic Acid Aqueous Gel Base" by Kazuhiro Morimoto et al; Journal of Pharmaceutical Sciences, vol. 73, No. 10, Oct. 1984.
Abstract of Japanese Kokai 118013/81.
Abstract of Japanese Kokai 122309/81.

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