Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1977-04-04
1978-10-17
Schenkman, Leonard
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
424316, A61K 3117
Patent
active
041209788
ABSTRACT:
Compounds selected from the group consisting of amines of the formula I ##STR1## in which R.sub.1 and R.sub.2 stand for a member selected from lower alkyl, lower alkenyl, cycloalkyl having 4 to 7 ring members, phenyl-lower alkyl, phenyl-lower alkyl substituted in the phenyl residue by a member selected from lower alkyl, lower alkoxy, halogen and trifluoromethyl, lower alkylene, oxa-lower alkylene, aza-lower alkylene and thia-lower alkylene, and one of R.sub.1 and R.sub.2 stands for hydrogen and the other has the above meanings, Ph stands for a member selected from meta- and para-phenylene and meta- and para-phenylene substituted by a member selected from lower alkyl, lower alkenyl, lower alkinyl, mercapto-lower alkyl, hydroxy-lower alkyl, phenyl, cyano, hydrogen, halogen, lower alkoxy, lower alkenyloxy, lower alkinyloxy, mono-, di and trihalogeno-lower alkyl, cycloalkyl having 5 to 7 ring members and phenoxy, and R.sub.3 stands for a member selected from lower alkyl and cycloalkyl having 5 to 7 ring member, and their condensation product with aldehydes and ketones, and their salts are useful as agents for the inhibition of the cardiac .beta.-receptors.
REFERENCES:
patent: 3408387 (1968-10-01), Howe et al.
patent: 3644520 (1972-02-01), Hartley et al.
patent: 3689524 (1972-09-01), Jacke et al.
patent: 3755413 (1973-08-01), Koppe et al.
Ciba-Geigy Corporation
Maitner John J.
Schenkman Leonard
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