Pharmaceutical composition for increasing bladder capacity

Details Pharmaceutical composition for increasing bladder capacity Pharmaceutical composition for increasing bladder capacity

1994-08-09

1996-03-05

Cintins, Marianne M.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514264, A61K 3152

Patent

active

054968232

ABSTRACT:
Pharmaceutical compositions for the improvement of dysuria comprising a pharmaceutical carrier and a therapeutically effective amount of a xanthine derivative represented by the general formula I ##STR1## wherein R.sub.1 denotes a group of the formula R.sub.4 -CO- or R.sub.5 R.sub.6 (OH)C- or a carboxyl group, wherein R.sub.4 and R.sub.5 independently denote an alkyl group having 1-3 carbon atoms, and R.sub.6 denotes a hydrogen atom or an alkyl group having 1-3 carbon atoms, R.sub.2 denotes a hydrogen atom, an alkyl group having 1-5 carbon atoms or an alkyloxy group having 1-5 carbon atoms, R.sub.3 denotes an alkyl group having 1-3 carbon atoms and n denotes 1-6 or a pharmaceutically acceptable acid addition salt thereof.
They are active in prolonging urination intervals and increasing urination threshold pressure with almost no influence upon constrictive force of the bladder. Thus, they are effective in treatment and prevention of dysuria such as pollakiuria and incontinence of urine.

REFERENCES:
patent: 4289776 (1981-09-01), Mohler et al.
Drugs of the Future, vol. VII, No. 2, 1982, "Propentofgylline", pp. 119-120.
Morikawa et al., Pharmacometrics, vol. 37, No. 1, pp. 27-37 (1989).
Journal of New Remedies & Clinics (Shin-yaku to Rinsho) vol. 38 No. 12, pp. 133-138 (Dec. 1989), Kimura et al.
Pharmacometrics (Oyu Yakuri) vol. 30, No. 4, pp. 661-676 (p. 661, summary item 2 and p. 673 tables 13 and 14), Sakurai et al., 1985.
Chemical Abstracts 95(23):197310s, 1981.
Chemical Abstracts 110(15):128285d, 1988.
Chemical Abstracts 116(21):209267a, 1991.
Goodman Gilman et al. "The Pharmacological Basis of Therapeutics" (6th Ed.) New York, MacMillan Publishing, 1980, pp. 924-925.

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