Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1995-12-19
1997-09-30
Henley, III, Raymond
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514276, 514356, 514474, 514561, A61K 31715, A61K 3151, A61K 3144, A61K 3134, A61K 31195
Patent
active
056725906
DESCRIPTION:
BRIEF SUMMARY
This application is A 371 of PCT/C294/00015 filed Jul. 12, 1994.
FIELD OF INVENTION
The invention concerns a pharmaceutical preparation for immunomodulating and adjuvant treatment and for prevention of weakening of the immunity system.
BACKGROUND OF THE INVENTION
Immunomodulating compositions used at present time for treatment of various immunodeficiencies, autoimmunological and malignant diseases may according to their composition and origin be divided into several groups. An important group of these compositions is formed e.g. by the thymus hormones produced by extraction of animal tissues and distributed under the designation Thymus V-fraction (Hoffmann LaRoche), Thymodulin and Leucotropina (Ellem), Tymunox (Cilag) or TFX (Polfa). A further group of lmmunomodulating compounds to which much attention is paid especially in the field of basic medical research are cytokins, which which are the main compounds controlling the immunity response at the cell level. The technology of gene engineering facilitates the preparation of recombinant proteins which are active components of immunomodulating compositions, e.g. Roferon (interferon alpha2),(Hoffmann LaRoche), or hematopoetic growth factor G-CSF (Hoffmann LaRoche), distributed under he designation Neupogen. The already classic therapy by the use of interleukin-2 was discussed at the congress IMMUNOTHERAPY OF INFECTIONS (Berlin, May 4 to 7, 1993) especially from the wievpoint of failing in a part of the patients. Dialyzates of leucocytes are also very popular immunomodulating agents. In the Czech Republic they are known as Transfer factor (Sevac). To the oldest and still most often used agents belong compounds on the basis of the adjuvant activity of selected antigens derived from the components of bacterial membranes, e.g. Stays (Sevac), Olimostimulin (Medical Faculty of the Palacky University, Olomouc). East medicine, especially in China, pays on the basis of the old tradition very big attention to immunostimulation compounds of plant origin and to the mechanism of their activity on the level of present europian research (Immunotherapy of Infections. Berlin. May 4 to 7, 1993).
A composition known from the Greek Patent Specification No. 72 440 (dr. T. H. Alivizatos), containing a mixture of D-ribose, DL-alanine, nicotinic acid and ascorbic acid may also be considered as a composition having a pronounced immunomodulating activity as this composition is able to rebuild the metabolic equilibrium and to strengthen the immnunity of the organism.
According to the modem conception of immunomodulating therapy targeted actions into the immunity of the organism are performed and it is necessary to define the area of the action and the character of the action of any pharmaceutical preparation. Such a definition is in case of most still used immunomodulating compounds very complicated and difficult. The reason of all these difficulties reside on one side in gaining some of the immunomodulating compounds from biological sources (and it is difficult to define all their possible biological activities, therefore) on the other side all these compounds have a number of biological activities that make the localization of their action in the regulating spheres of the immunity system impossible. Therapy based on the application of individual cytokines is according to present experience complicated by a number of risks which ape the result of involving of autoregulation mechanisms of the recipient of cytokins and successively the efficiency of the immunity system becomes lowered. It is also known that the activation of the immunity system by an exogenous cytokine is not of full value as further natural components are missing. For this reason it would be very desirable to prepare an immunomodulation preparation which would activate the system on a "physiological level", that means under involving all natural regulating and controlling spheres.
DESCRIPTION OF THE INVENTION
The object of the invention resides in a pharmaceutical composition for immunomodulating and adjuvant
REFERENCES:
patent: 4514387 (1985-04-01), Wissler
Aliatros Medical, a.s.
Henley III Raymond
Jacobs Bruce F.
Van Eyl Diderico
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