Pharmaceutical composition for diabetic neuropathy

Details Pharmaceutical composition for diabetic neuropathy Pharmaceutical composition for diabetic neuropathy

2006-07-11

2006-07-11

Lewis, Patrick T. (Department: 1623)

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

C514S043000, C514S049000, C514S050000

Reexamination Certificate

active

07074773

ABSTRACT:
The present invention relates to an agent for the prophylaxis or treatment of diabetic neuropathy, which contains cytidine 5′-diphosphocholine (CDP-choline) as an active ingredient. The agent for the prophylaxis or treatment of diabetic neuropathy of the present invention is effective for neuropathy mainly caused by metabolic disturbance of carbohydrate and is also superior in safety. Neuropathy includes peripheral neuropathy and dysautonomia. CDP-choline is effective even by oral administration.

REFERENCES:
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patent: 00/11952 (2000-03-01), None
M. Ohsawa et al., “Possible Involvement of Spinal Protein Kinase C in Thermal Allodynia and Hyperalgesia in Diabetic Mice”, European Journal of Pharmacology, 372, pp. 221-228, 1999.
J. Secades et al., “CDP-Choline: Pharmacological and Clinical Review”, Methods Find Exp. Clinical Pharmacol., vol. 17, Suppl. B, pp. 1-54, 1995.
Lopez et al., “Effects of orally administered cytidine 5′-diphosphate choline on brain phospholipid content”, J. Nutr. Biochem., vol. 3, No. 6, pp. 313-315, 1992 (abstract).

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