Pharmaceutical composition containing water soluble drug

Details Pharmaceutical composition containing water soluble drug Pharmaceutical composition containing water soluble drug

2011-03-01

2011-03-01

Wax, Robert A (Department: 1615)

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

C427S002190

Reexamination Certificate

active

07897179

ABSTRACT:
The present invention is directed to a process of preparing beads coated with a water soluble drug for incorporation into a pharmaceutical composition comprising: (a) preparing a supersaturated drug solution containing a desired amount of drug, which is completely saturated at a first temperature but which is supersaturated at a second temperature which is below the first temperature; and (b) coating inert beads with the drug solution, said drug solution being maintained at or below the first temperature but above the second temperature, and said beads maintained at a second temperature, wherein the second temperature is less than the first temperature and wherein the solution containing the drug is supersaturated at the second temperature, as well as to the pharmaceutical compositions containing same.

REFERENCES:
patent: 5302400 (1994-04-01), Sipos
patent: 5362517 (1994-11-01), Flesher et al.
patent: 5833891 (1998-11-01), Subramaniam et al.
patent: 6267985 (2001-07-01), Chen et al.
patent: 6294192 (2001-09-01), Patel et al.
patent: WO 99/12848 (1999-03-01), None
patent: WO 03/103637 (2003-12-01), None
patent: WO 2004/047718 (2004-06-01), None
Remington's Pharmaceutical Sciences, Eighteenth Edition, 1990, p. 209.
Physicians' Desk Reference, 49 Edition, 1995, p. 2664.

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