Pharmaceutical composition containing high drug load and method

Details Pharmaceutical composition containing high drug load and method Pharmaceutical composition containing high drug load and method

1989-03-15

1991-09-17

Page, Thurman K.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Particulate form

424452, 424458, 424489, 424493, 424494, A61K 916, A61K 950

Patent

active

050493949

ABSTRACT:
A pharmaceutical composition in the form of beads prepared by an extrusion-spheronization technique and containing more than 80% by weight drug, less than 15% by weight non-lipophilic binder-plasticizer, such as microcrystalline cellulose to achieve required plasticity for processing, a starch-based excipient such as sodium starch glycolate or pregelatinized starch to control water/fluid distribution and thereby inhibit agglomeration during processing, and water-soluble binder such as hydrolyzed gelatin to make the final beads less friable. During processing a granulating agent such as ethanol/water is added to improve blend properties and control during spheronization. A method for preparing the above beads is also provided.

REFERENCES:
patent: 4711777 (1987-12-01), Tan et al.
patent: 4808413 (1989-02-01), Joshi et al.

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