Pharmaceutical composition containing a stable modification of t

Details Pharmaceutical composition containing a stable modification of t Pharmaceutical composition containing a stable modification of t

1987-10-20

1989-04-18

Rotman, Alan L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Having -c-, wherein x is chalcogen, bonded directly to...

514346, 546291, 546294, C07D21374, C07D21375, A61K 3144

Patent

active

048228079

ABSTRACT:
The present invention provides a process for the preparation of cystalline torasemide in the pure modification I (monoclinic, space group P2.sub.1 /c, melting point 162.degree. C.) from torasemide of modification II (monoclinic, space group P2
, melting point 169.degree. C.), wherein a suspension of torasemide of modification II is stirred in water with the addition of a catalytic amount of modification I until the rearrangement is complete.
The present invention also provides pharmaceutical compositions containing torasemide of modification I.

REFERENCES:
patent: Re30633 (1977-04-01), DeLarge et al.
patent: 4018929 (1977-04-01), DeLarge et al.
Chem. Abstracts, vol. 92(15), abst. no. 128,739e, Apr. 14, 1980.
Chem. Abstracts, vol. 95(25), abst. no. 214,829n, Dec. 21, 1981.
Chem. Abstracts, vol. 97(21), abst. no. 174,700w, Nov. 22, 1982.
REMINGTONS' PHARMACEUTICAL SCIENCES, Fourteenth Edition, pp. 140-142, 170, 208-221, Mack Publishing Co., (1970).
Dupont et al., "Structure Cristalline et Moleculaire dun Divretigue . . . ", Acta Cryst. B34, 1304-1310, (1978).
Dupont et al., "Structure dune Seconde Variete de la Torasemide", Acta Cryst. B34, 2659-2662, (1978).

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