Pharmaceutical composition containing a local anesthetic and/or

Details Pharmaceutical composition containing a local anesthetic and/or Pharmaceutical composition containing a local anesthetic and/or

1991-01-22

1993-09-14

Fay, Zohreh A.

Drug, bio-affecting and body treating compositions

Preparations characterized by special physical form

Liposomes

514330, A61K 3722, A61K 31445

Patent

active

052446786

ABSTRACT:
The present invention relates to a pharmaceutical composition containing a local anesthetic or a centrally acting analgesic, comprising a lipophilic portion, the anesthetic or analgesic being encapsulated in liposomes.

REFERENCES:
patent: 3993754 (1976-11-01), Rahman et al.
patent: 4186183 (1980-01-01), Steck et al.
patent: 4419348 (1983-12-01), Rahman et al.
patent: 4622219 (1986-11-01), Haynes
Chemical Abstracts, vol. 94, 1981, p. 66, No. 58303h, by T. Okano et al., "Duration of the local anesthetic action of dibucaine by liposomes and its mechanism" & Yakugaku Zasshi 1980, 100(11), 1097-103.
Chemical Abstracts, vol. 96, 1982, p. 136, No. 116500z, Columbus, Ohio; "Enhanced analgesic activity of liposomised Met-enkephalin analog" & Indian J. Biochem. Biophys. 1981, 18(6), 440-1.
Chemical Abstracts, vol. 86, 1977, p. 26, No. 165153r, Columbus, Ohio, by P. L. Yeagle et al., "Molecular dynamics of the local anesthetic tetracaine in phospholipid vesicles" & Biophys. Acta 1977, 465(2), 173-8.
Biochimca et Biophsyica Acta, vol. 799, 1984, pp. 195-198, Elsevier Science Publishers B.V.; Naomi Kraus-Friedman et al.; "Lipsome encapsulated tetracaine lowers bood glucose".
Chemical Abstract 104: 39720a (1986).

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