Drug – bio-affecting and body treating compositions – Antigen – epitope – or other immunospecific immunoeffector – Recombinant or stably-transformed bacterium encoding one or...
Patent
1976-11-29
1978-10-24
Coughlan, Jr., Paul M.
Drug, bio-affecting and body treating compositions
Antigen, epitope, or other immunospecific immunoeffector
Recombinant or stably-transformed bacterium encoding one or...
544244, 544277, A61K 31675
Patent
active
041221737
ABSTRACT:
2-Dimethylamino-6-diethyleneimidophosphamido-7-methylpurine having the formula ##STR1## A method for preparing 2-dimethylamino-6-diethyleneimido-phosphamido-7-methylpurine consisting of treating theo-bromine with heating to the boiling point and subsequently with phosphorus oxychloride and phosphorus pentachloride. The prepared 2,6-dichloro-7-methylpurine is heated to 50.degree. - 60.degree. C in an aqueous solution of ammonia and the resulting 2-chloro-6-amino-7-methylpurine is reacted, with heating, with a aqueous solution of dimethylamine. The obtained 2-dimethylamino-6-amino-7-methylpurine is reacted, at the boiling point, with either phosphorus oxychloride, or phosphorus pentachloride and formic acid. The resulting 2-dimethylamino-7-methylpurinyl-6-aminophosphoric dichloroanhydride is then treated with ethyleneimine in a medium of an organic solvent in the presence of an acceptor of hydrogen chloride, and the final product is then isolated.
A preparation for treating malignant tumors of the haemopoietic system, containing 2-dimethylamino-6-diethyleneimidophosphamido-7-methylpurine as the active principle is provided.
REFERENCES:
patent: 3201313 (1965-08-01), Bardos et al.
patent: 3666748 (1972-05-01), Honjo et al.
patent: 3865830 (1975-02-01), Turkevich et al.
Chaman Elena Silvestrovna
Chernov Vladimir Alexandrovich
Golovchinskaya Elena Semenovna
Korsunsky Vyacheslav Sergeevich
Nikolaeva Ljudmila Alexandrovna
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