Pharmaceutical composition containing 2-amino-6-chloropurine-9-.

Details Pharmaceutical composition containing 2-amino-6-chloropurine-9-. Pharmaceutical composition containing 2-amino-6-chloropurine-9-.

1989-12-05

1996-12-03

Kunz, Gary L.

Drug, bio-affecting and body treating compositions

Designated organic active ingredient containing

Carbohydrate doai

536 2714, A61K 3170, C07H 19173

Patent

active

055808603

ABSTRACT:
An anti-AIDS virus agent is disclosed, which is characterized in that it contains the 2',3'-dideoxypurinenucleosides represented by the chemical formula (I): ##STR1## as an effective ingredient.

REFERENCES:
patent: 5053499 (1991-10-01), Kojima et al.
APP Environ Microbiol 55 (2) 419-24 (1989).
Chemical Pharmaceutical Bull 36 (10) 4153-6 (1988).
Synthesis (9) 670-4 (1988), Nucleic Acids Symposium Series 20 17 (1988).
J. AM. Chem. Soc., vol. 111, No. 22, Oct. 25, 1989, pp. 8502-8504, V. Nair, et al., "Novel, Stable Congeners of The Antiretroviral Compound 2',3'-Dideoxyadenosine" (cited Mar. 20, 1991).
J. Biolog. Chem., vol. 263, No. 12, Apr. 25, 1988, pp. 5870-5875, T. Haertle, et al., "Metabolism and Anti-Human Immuno-Deficiency Virus-1 Activity of 2-Halo-2', 3'-Dideoxyadenosine Derivatives* ".
J. Med. Chem., vol. 32, May 1989, pp. 1135-1140, A. Rosowsky, et al., "Synthesis of the 2-Chloro Analogues of 3'-Deoxy-Adenosine, 2', 3'-Dideoxyadenosine, and 2', 3'-Didehydro-2', 3'-Dideoxyadenosine as Potential Antiviral Agents".
Biochem. Biophys. Res. Commum., vol. 145, No. 1, May 29, 1987, pp. 277-283, J. Balzarini, et al., "The 2', 3'-Dideoxyriboside of 2,6-Diaminopurine and its 2', 3'-Didehydro Derivative Inhibit The Deamination of 2', 3'-Dideoxyadenosine, an . . . ".
Anticancer Research, vol. 7, Oct. 15-18, 1987, pp. 1023-1038, E. De Clercq, "Perspectives For The Chemotherapy of Aids".
Nair et al. (1989) J. Am. Chem. Soc., vol. 111, pp. 8502-8504.

Affiliated with

Also associated with

Rating

Pharmaceutical composition containing 2-amino-6-chloropurine-9-. does not yet have a rating. At this time, there are no reviews or comments for this patent.

If you have personal experience with Pharmaceutical composition containing 2-amino-6-chloropurine-9-., we encourage you to share that experience with our LandOfFree.com community. Your opinion is very important and Pharmaceutical composition containing 2-amino-6-chloropurine-9-. will most certainly appreciate the feedback.

Rate now

Comments { 0 }

Profile ID: LFUS-PAI-O-785691