Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Carbohydrate doai
Patent
1994-12-02
1997-10-21
Fonda, Kathleen K.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Carbohydrate doai
514658, 514886, A61K 31715, A61K 31135
Patent
active
056796609
ABSTRACT:
A method of preparing an injectable pharmaceutical or veterinary composition which comprises either diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, or an inclusion complex of diclofenac or a salt thereof and 2-hydroxypropyl beta-cyclodextrin, includes the step of dissolving either the diclofenac or salt thereof and the 2-hydroxypropyl beta-cyclodextrin, or the inclusion complex, in water to form a solution, the water having been acidified to a pH such that the pH of the solution is from 6.0 to 8.5 inclusive, in the absence of a phosphate buffer. The composition so produced has good stability on storage.
REFERENCES:
patent: 4983586 (1991-01-01), Bodor
Journal of Pharmaceutical Sciences, vol. 83, No. 9, Sep. 1994, "In Vitro Corneal Permeability of Diclofenac Sodium in Formulations Containing Cyclodextrins Compared to the Commercial Product Voltraren Ophtha", Olaf Reer et al., pp. 1345-1349.
Elsevier Science Publishers B.V. (Biomedical Division), 1987, "Cyclodextrin Inclusion Compounds: Effects on Stability and Bio-Pharmaceutical Properties", K. Uekama, pp. 181-193.
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M. Otagiri et al., "Comparative Study on Inclusion Complexation of .beta.-Cyclodextrin and Tri-O-Methyl-.beta.-Cyclodextrin with Several Drugs in Aqueous Solution", Acta Pharm. Suec. 21, pp. 357-366, 1984.
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English Abstract(s) of JP-A-60-16547 to Wakamoto Pharm. Co., Ltd., 1994.
Bodley Mark David
Glintenkamp Lueta Ann
Penkler Lawrence John
van Oudtshoorn Michiel Coenraad Bosch
Farmarc Nederland BV
Fonda Kathleen K.
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