Pharmaceutical composition comprising crystalline...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Radical -xh acid – or anhydride – acid halide or salt thereof...

Reexamination Certificate

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Details

C514S553000, C514S646000, C562S115000, C562S114000, C562S030000, C564S394000, C564S442000

Reexamination Certificate

active

06900245

ABSTRACT:
The present invention relates to a pharmaceutical composition for treating or preventing obesity, comprising novel crystalline sibutramine methanesulfonate hemihydrate of formula (I). The crystalline sibutramine methanesulfonate hemihydrate according to the present invention has a much higher solubility in water, and enhanced stability under a high humidity/temperature condition, as compared with sibutramine hydrochloride monohydrate

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patent: 2184122 (1982-11-01), None
patent: 2098302 (1987-06-01), None

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