Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Capsules
Patent
1991-11-25
1993-05-25
Waddell, Frederick E.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Capsules
424 7801, 424468, 514867, A61K 958, A61K 922, A61K 3174
Patent
active
052138062
ABSTRACT:
A pharmaceutical composition capable of being disintegrated in an acidic environment, which comprises calcium polycarbophil and 1 to 80% by weight of a cellulose derivative such as carboxymethylcellulose or low substituted hydroxypropylcellulose based on the calcium polycarbophil. The pharmaceutical composition in a form of a tablet, a capsule, or granules is useful as a bulk-forming laxative or an antidiarrheic agent since it can be disintegrated readily in the stomach and form a complete dispersion of polycarbophil in the digestive tract.
REFERENCES:
patent: 3297664 (1967-01-01), Miskel
Chemical Abstracts (109: 216036h) 1988.
Handbook of Nonprescription Drugs, 5th Edition, pp. 31-35, 1977.
Product publication for "FiberCon" Lederle Laboratories Division, American Cyanamid Company, 1986.
Hung Seng Ch'ng et al, "Bioadhesive Polymers as Platforms for Oral Controlled Drug Delivery II: . . . Synthesis" Journal of Pharmaceutical Science, vol. 74, No. 4, Apr. 1985 pp. 399-405.
Ivan E. Danhorf, "Pharmacology, Toxicology, Clinical Efficacy, and Adverse Effects of Calcium Polycarbophil, an Enteral Hydrosorptive Agent", Pharmacotherpy 1982, pp. 18-28 vol. 2 No. 1.
Ishibashi Takeo
Ito Yasuo
Kato Hideo
Kitayama Masakazu
Nagata Osamu
Hokuriku Pharmaceutical Co., Ltd.
Waddell Frederick E.
Weddington K.
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