Drug – bio-affecting and body treating compositions – Enzyme or coenzyme containing – Transferases
Reexamination Certificate
2005-06-20
2008-08-19
Nashed, Nashaat T. (Department: 1652)
Drug, bio-affecting and body treating compositions
Enzyme or coenzyme containing
Transferases
C435S232000, C435S191000, C435S018000, C435S069100, C435S320100, C536S023200
Reexamination Certificate
active
07413735
ABSTRACT:
The present invention relates to a pharmaceutical composition for inhibiting angiogenesis which comprises arginine deiminase as an active ingredient, where the arginine deiminase, obtained fromMycoplasma argininior prepared by a genetic recombination technique, may be conjugated to an activated polymer to lower its immunogenecity and increase its life time. The pharmaceutical composition of the present invention exhibits an excellent inhibitory activity against angiogenesis.
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Misawa et al. High-level expression ofMycoplasma argininedeiminase inEscherichia coliand its efficient renaturation as an anti-tumor enzyme, J Biotechnol. Aug. 15, 1994;36(2):145-55.
Branden et al. Introduction to protein structure, Gerald Publishing Inc., New York, p. 247, 1991.
Witkowski et al. Conversion of a beta-ketoacyl synthase to a malonyl decarboxylase by replacement of the active-site cysteine with glutamine, Biochemistry. Sep. 7, 1999;38(36):11643-50.
Seffernick et al. Melamine deaminase and atrazine chlorohydrolase: 98 percent identical but functionally different, J Bacteriol. Apr. 2001;183(8):2405-10.
Chun Boe-Gwun
Kang Sang-Wook
Kim Min-Young
Min Bon-Hong
Moon Chang-Hee
Angio Lab, Inc.
Baker & Hostetler LLP
Chowdhury Iqbal
Nashed Nashaat T.
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