Drug – bio-affecting and body treating compositions – Preparations characterized by special physical form – Tablets – lozenges – or pills
Patent
1986-08-14
1989-07-04
Page, Thurman K.
Drug, bio-affecting and body treating compositions
Preparations characterized by special physical form
Tablets, lozenges, or pills
424470, 424472, 424475, 424477, 424479, 424480, 424481, 424482, 424499, 424500, 424501, 424502, A61K 920, A61K 924, A61K 950
Patent
active
048449075
ABSTRACT:
A pharmaceutical composition in the form of a multiphase (especially a bilayered, optionally coated) tablet. The tablet has a narcotic analgesic phase containing a therapeutically effective quantity of a narcotic analgesic or an analgesically effective salt thereof (e.g. codeine phosphate) and a non-steroidal anti-inflammatory phase containing a therapeutically effective quantity of a non-steroidal anti-inflammatory carboxylic acid or an anti-inflammatory salt or ester thereof (e.g. ibuprofen). The narcotic analgesic phase is free from a non-steroidal anti-inflammatory carboxylic acid or salt or ester thereof, stearic acid and stearate salt, and the non-steroidal anti-inflammatory phase is free from a narcotic analgesic or salt thereof, stearic acid and a stearate salt. Further, both the narcotic analgesic phase and the non-steroidal anti-inflammatory phase contain a self-lubricating, compression aid, especially a self-lubricating, direct compression aid, such as microcrystalline cellulose.
REFERENCES:
patent: 2738303 (1956-03-01), Blythe
patent: 3558768 (1971-01-01), Klippel
patent: 3950508 (1976-04-01), Mony et al.
patent: 4601894 (1986-07-01), Hanna et al.
patent: 4606909 (1986-08-01), Bechgaard et al.
Elger Gordon A.
Leslie Stewart T.
Malkowska Sandra T. A.
Miller Ronald B.
Neale Philip J.
Euroceltique S.A.
Page Thurman K.
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