Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Heterocyclic carbon compounds containing a hetero ring...
Patent
1988-08-12
1989-10-03
Goldberg, Jerome D.
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Heterocyclic carbon compounds containing a hetero ring...
A61K 31555
Patent
active
048717282
ABSTRACT:
The invention refers to a novel pharmaceutical composition having especially antimycotic activity and comprising the zinc complex of 5-chloro-7-iodo-8-hydroxyquinoline of formula (I) ##STR1## and one or more pharmaceutically acceptable carriers. The pharmaceutical composition of the invention can be used for the effective treatment of mycotic infections on the skin surface, mucous membranes or nails.
The complex of formula (I) is prepared by reacting a solution of an alkali metal salt of 5-chloro-7-iodo-8-hydroxyquinoline with a solution containing an excess of an inorganic or organic zinc salt or a zinc complex having a lower stability constant than that of the complex of formula (I) and separating the product precipitated.
REFERENCES:
Chemical Abstract 83:157288m (1975).
Chemical Abstract 88:108h (1978).
Kidani (1974) Bunseki Kagaku 23 (11):1375-1378.
Urakubo (1976) Eisei Shikensho Hokoku (94):32-35.
Egri Janos
Fekete Marton
Gorgenyi Frigyes
Kovacs Marta
Miholics Gizelle
EGIS Cyogyszergvar
Goldberg Jerome D.
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