Drug – bio-affecting and body treating compositions – Conjugate or complex of monoclonal or polyclonal antibody,...
Reexamination Certificate
2004-11-13
2010-06-15
Ouspenski, Ilia (Department: 1644)
Drug, bio-affecting and body treating compositions
Conjugate or complex of monoclonal or polyclonal antibody,...
C514S012200
Reexamination Certificate
active
07736653
ABSTRACT:
Disclosed is a novel use of an immunoglobulin Fc fragment, and more particularly, a pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier. The pharmaceutical composition comprising an immunoglobulin Fc fragment as a carrier remarkably extends the serum half-life of a drug while maintaining the in vivo activity of the drug at relatively high levels. Also, when the drug is a polypeptide drug, the pharmaceutical composition has less risk of inducing immune responses compared to a fusion protein of the immunoglobulin Fc fragment and a target protein, and is thus useful for developing long-acting formulations of various polypeptide drugs.
REFERENCES:
patent: 5045312 (1991-09-01), Aston et al.
patent: 5116964 (1992-05-01), Capon et al.
patent: 5225538 (1993-07-01), Capon et al.
patent: 5349053 (1994-09-01), Landolfi
patent: 5428130 (1995-06-01), Capon et al.
patent: 5447851 (1995-09-01), Beutler et al.
patent: 5455165 (1995-10-01), Capon et al.
patent: 5514582 (1996-05-01), Capon et al.
patent: 5585097 (1996-12-01), Bolt et al.
patent: 5605690 (1997-02-01), Jacobs et al.
patent: 5650150 (1997-07-01), Gillies
patent: 5672688 (1997-09-01), Kobayashi et al.
patent: 5712121 (1998-01-01), Devos et al.
patent: 5714147 (1998-02-01), Capon et al.
patent: 5723125 (1998-03-01), Chang et al.
patent: 5843725 (1998-12-01), Sledziewski et al.
patent: 5844099 (1998-12-01), Stahl et al.
patent: 5908626 (1999-06-01), Chang et al.
patent: 5977310 (1999-11-01), Namiki et al.
patent: 6018026 (2000-01-01), Sledziewski et al.
patent: 6030613 (2000-02-01), Blumberg et al.
patent: 6117656 (2000-09-01), Seed
patent: 6165476 (2000-12-01), Strom et al.
patent: 6277375 (2001-08-01), Ward
patent: 6291212 (2001-09-01), Sledziewski et al.
patent: 6291646 (2001-09-01), Sledziewski et al.
patent: 6300099 (2001-10-01), Sledziewski et al.
patent: 6307025 (2001-10-01), Hession et al.
patent: 6323323 (2001-11-01), Sledziewski et al.
patent: 6340742 (2002-01-01), Burg et al.
patent: 6406697 (2002-06-01), Capon et al.
patent: 6410008 (2002-06-01), Strom et al.
patent: 6444792 (2002-09-01), Gray et al.
patent: 6451313 (2002-09-01), Maddon et al.
patent: 6482919 (2002-11-01), Ledbetter et al.
patent: 6541610 (2003-04-01), Smith
patent: 6620413 (2003-09-01), DeSauvage et al.
patent: 6656728 (2003-12-01), Kavanaught et al.
patent: 6660843 (2003-12-01), Feige et al.
patent: 6677136 (2004-01-01), Marshall et al.
patent: 6743778 (2004-06-01), Kohno
patent: 6756480 (2004-06-01), Kostenuik et al.
patent: 7125843 (2006-10-01), DeFrees et al.
patent: 2001/0053539 (2001-12-01), Lauffer et al.
patent: 2002/0037558 (2002-03-01), Lo et al.
patent: 2002/0081664 (2002-06-01), Lo et al.
patent: 2003/0073164 (2003-04-01), Simmons et al.
patent: 2003/0082679 (2003-05-01), Sun et al.
patent: 2003/0082749 (2003-05-01), Sun et al.
patent: 2003/0229023 (2003-12-01), Oliner et al.
patent: 2004/0044188 (2004-03-01), Feige et al.
patent: 2004/0053845 (2004-04-01), Feige et al.
patent: 2004/0181033 (2004-09-01), Han et al.
patent: 2005/0163799 (2005-07-01), Mann et al.
patent: 2006/0094083 (2006-05-01), Choi et al.
patent: 2006/0269553 (2006-11-01), Kim et al.
patent: 0 464 533 (1992-01-01), None
patent: 62-201582 (1987-09-01), None
patent: 10-0249572 (1999-12-01), None
patent: 10-0316347 (2001-11-01), None
patent: 2003-0009464 (2003-01-01), None
patent: 9004413 (1990-05-01), None
patent: 9116354 (1991-10-01), None
patent: 9210507 (1992-06-01), None
patent: 9700319 (1997-01-01), None
patent: 97/24137 (1997-07-01), None
patent: 99/02709 (1999-01-01), None
patent: 00/23472 (2000-04-01), None
patent: 00/40615 (2000-07-01), None
patent: 00/69913 (2000-11-01), None
patent: 01/03737 (2001-01-01), None
patent: 0246227 (2002-06-01), None
patent: 02/066514 (2002-08-01), None
patent: 03076567 (2003-09-01), None
patent: 2004/081053 (2004-09-01), None
patent: 2004101739 (2004-11-01), None
patent: 2004101740 (2004-11-01), None
patent: 2004108885 (2004-12-01), None
patent: 2005001025 (2005-01-01), None
patent: 2005017148 (2005-02-01), None
patent: 2005037989 (2005-04-01), None
patent: 2005/047336 (2005-05-01), None
patent: 2005073383 (2005-08-01), None
Bentz et al., “Improved local delivery of TGF-β2 by binding to injectable fibrillar collagen via difunctional polyethylene glycol,”J. Biomed. Mat. Res. 39(4):539-548, 1998.
van der Poll et al., “Effect of a Recombinant Dimeric Tumor Necrosis Factor Receptor on Inflammatory Responses to Intravenous Endotoxin in Normal Humans,”Blood89(10):3727-3734, May 15, 1997.
Choi In Young
Jung Sung Youb
Kim Chang Hwan
Kim Young Min
Kwon Se Chang
Hanmi Pharm. Co., Ltd
Ouspenski Ilia
Sughrue & Mion, PLLC
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