Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...
Reexamination Certificate
2005-01-18
2005-01-18
Kim, Vickie (Department: 1614)
Drug, bio-affecting and body treating compositions
Designated organic active ingredient containing
Having -c-, wherein x is chalcogen, bonded directly to...
C514S618000, C514S419000
Reexamination Certificate
active
06844361
ABSTRACT:
This invention is directed to a pharmaceutical composition comprising the sodium-hydrogen exchanger (NHE) inhibitor cariporide and an angiotensin converting enzyme (ACE) inhibitor which exhibits unexpectedly efficacious properties for preventing heart failure and other age-related organ dysfunctions, age-related disorders and for prolonging life, and to methods of preventing heart failure and other age-related organ dysfunctions, age-related disorders and for prolonging life comprising administering pharmaceutically effective amounts of the sodium-hydrogen exchange inhibitor cariporide and an ACE inhibitor.
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Linz, et al., Long-Term ACE INhibition Doubles Lifespan of Hypertensive Rats, Circulation. 1997;96:3164-3172, American Heart Association, XP-002239742.
Ruetten, et al., The NHE1 Inhibitor Cariporide Improves Left Ventricular Morphology and Function in Rats with Chronic Heart Failure in Combination with the ACE Inhibitor Ramipril, Abstract from Scientific Sessions; XP-001147832, ID No.: 117084, Nov. 20, 2002.
Linz Wolfgang
Schindler Ursula
Aventis Pharma Deutschland GmbH
Kim Vickie
Kwon Brian S.
Wang George
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