Pharmaceutical composition comprising...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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Details

C514S312000, C514S322000, C514S375000

Reexamination Certificate

active

07943623

ABSTRACT:
A pharmaceutical composition according to the present invention comprises: (I) at least one member selected from the group consisting of oxazole compounds, optically active isomers thereof, and salts thereof, the oxazole compounds being represented by general formula (1): wherein R1represents a hydrogen atom or C1-6alkyl group; n represents an integer from 0 to 6; and R2represents, for example, a group of general formula (A) shown below: wherein R3represents a phenoxy group, optionally substituted on the phenyl ring with one or more members selected from the group consisting of halogen atoms, halo-substituted or unsubstituted C1-6alkyl groups, and halo-substituted or unsubstituted C1-6alkoxy groups; and (II) at least one cellulose compound selected from the group consisting of hydroxypropyl methylcellulose phthalate and hydroxypropyl methylcellulose acetate succinate. The present pharmaceutical composition has an improved oxazole compound water solubility.

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Kuppuswamy Nagarajan, et al.: Nitroimidazoles XXI 2,3-dihydro-6-nitroimidazo[2,1-b] oxazoles with antitubercular activity; Eur. J. Med. Chem 24 (1989) 631-633.
Dilip R. Ashtekar, et al.: In Vitro and in Vivo Activities of the Nitroimidazole CGI 17341 againstMycobacterium tuberculosis; Antimicrobial Agents and Chemotherapy, Feb. 1993, p. 183-186; vol. 37, No. 2.

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