Pharmaceutical composition based on a polymorphic form I of...

Drug – bio-affecting and body treating compositions – Designated organic active ingredient containing – Having -c- – wherein x is chalcogen – bonded directly to...

Reexamination Certificate

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C514S454000

Reexamination Certificate

active

10722451

ABSTRACT:
Pharmaceutical composition comprising 5 to 20% of an idazoxan salt or of idazoxan hydrate, 10 to 40% of microcrystalline cellulose, 1 to 5% of lubricant, 0.1 to 0.5% of colloidal silica and from 29.5% to 84.8% of lactose, with respect to the total mass.

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patent: 4818764 (1989-04-01), Chapleo et al.
patent: 5487901 (1996-01-01), Conte et al.
patent: 5492907 (1996-02-01), Pickar et al.
patent: 92-14694 (1992-12-01), None
patent: 96-03674 (1996-03-01), None
patent: WO 01/39740 (2001-06-01), None
Reckitt & Colman, “Idazoxan Hydrochloride”, Drug of the Future, 10, p. 782, 1985.
F.C. Colpaert, “Pharmacological Characteristics of Tremor, Rigidity and Hypokinesia Induced by Reserpine in Rat”, Neuropharmacology, vol. 26, No. 9, pp. 1431-1140, 1987.
F.C. Colpaert, “Effect of an Alpha Antagonist in a 20-Year-Old Java Monkey With MPTP-Induced Parkinsonian Signs”, Brain Research Bulletin, vol. 26, pp. 627-631, 1991.
B. Scatton et al., Behavioural Pharmacology 2000, vol. 11, Nos. 3 and 4, 243-256.

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